A Bio-inspired Hypoxia Sensor using HIF1a-Oxygen-Dependent Degradation Domain
نویسندگان
چکیده
منابع مشابه
Bio-inspired enol-degradation for multipurpose oxygen sensing.
Inspired by the enol-degradation of luciferin, a new oxygen sensor with oppositely changed color and fluorescence has been designed. This new reaction-based dual mode sensor can not only be used as a highly selective instant "fluorescence on" oxygen probe, but also as a freshness indicator of food or food materials by using its property of time-adjustable color fading.
متن کاملc-Jun protects hypoxia-inducible factor-1alpha from degradation via its oxygen-dependent degradation domain in a nontranscriptional manner.
Although hypoxia-inducible factor-1alpha (HIF-1alpha) has long been intensively investigated as a drug target by interfering with its expression or transcriptional function, the regulatory mechanisms of HIF-1alpha remain to be further clarified. We report here that c-Jun associates with HIF-1alpha via its oxygen-dependent degradation domain, masks the sites for ubiquitination, and thus protects...
متن کاملSelf-Organization in Sensor Networks using Bio-Inspired Mechanisms
Bio-inspired communication methodologies promise to enable more scalable self-organizing network infrastructures. Especially in the area of mobile ad hoc sensor networks, such solutions are required in order to qualify them for simplified development and deployment based on autonomously evolving mechanisms to work on global tasks, i.e. to show an emergent behavior. In this paper, we introduce t...
متن کاملBio-Inspired Miniature Direction Finding Acoustic Sensor
A narrowband MEMS direction finding sensor has been developed based on the mechanically coupled ears of the Ormia Ochracea fly. The sensor consists of two wings coupled at the middle and attached to a substrate using two legs. The sensor operates at its bending resonance frequency and has cosine directional characteristics similar to that of a pressure gradient microphone. Thus, the directional...
متن کاملOptimization Of Bio-inspired Hair Sensor Arrays
Crickets use a pair of hairy appendages on their abdomen called cerci, each of which contains numerous mechano-receptive filiform hairs (Fig. 1). These sensitive hairs can respond even to the slightest air movements, down to 0.03 mm/s, generated by the approaching predators and initiating an escape mechanism in the crickets [1]. Bio-mimicking the cricket cerci, arrays of artificial hair sensors...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-43618-4